- University of Colorado (Aurora, CO)
- …of pluripotent stem cells into a variety of cell types, and CRISPR-Cas9-mediated gene targeting . Laboratory duties will involve receiving laboratory reagents and ... including melanoma and other skin cancers, and development of approaches to gene therapy in the skin. The Dermatopathology unit provides pathology services to… more
- University of Michigan (Ann Arbor, MI)
- …consult with the Core in all phases of genome editing, transgenic and gene targeting research from experimental design to mouse breeding. The Transgenic ... Core also offers a full suite of cryopreservation and assisted reproduction (IVF) services. The Core's mission is to provide access to complex technology that allows Principal Investigators to focus on their research instead of developing the tools for their… more
- Actalent (Brooklyn, NY)
- …streamline an integrated platform for creating human PSC models including generation of targeting vectors, gene -editing tools and genotyping assays for use by ... industry research lab + 3 years or more experience targeting and culturing human PSC lines (pluripotent stem cells)...cells (PSCs) to produce RNAi and KI/KO models using gene editing techniques. They will initially report to the… more
- Sandia National Laboratories (Livermore, CA)
- …using various CRISPR systems to alter gene expression through genome editing, gene activation or mRNA targeting tools. The selected candidate will continue ... genomics assays using several types of CRISPR screens (eg knockout, activation, mRNA targeting ) + Develop cell reporter assays + Design viral vectors for in vivo… more
- Memorial Sloan-Kettering Cancer Center (New York, NY)
- …current funded projects exploring modifiers of penetrance of germline homologous repair gene variants, targeting of inherited nucleotide repair deficiency, and ... developing of neo-antigen vaccines for syndromes associated with replication repair deficiencies , for example. C ross-departmental collaborative programs that provide opportunity for growth include the young adult population through the the Lisa and Scott… more
- Bio-Techne (Minneapolis, MN)
- …will help develop and execute the commercial product strategy for Cell and Gene Therapy (CGT) products within Bio-Techne that offer significant promise to treat life ... of experience** + **Must have experience and understanding of the Cell and Gene Therapy market** + **Strong business acumen and aptitude for customer requirements**… more
- Lilly (Indianapolis, IN)
- …includes active investments in Oligonucleotide development, nanomedicines for tissue specific targeting and other gene delivery strategies. The drug product ... team is also investing in building new platforms to support complex formulations such as lipid nanoparticles, Antibody Drug Conjugates and AAV and other non-viral vector delivery. We are seeking highly motivated professionals with an experience in developing… more
- Lilly (Indianapolis, IN)
- …includes active investments in Oligonucleotide development, nanomedicines for tissue specific targeting and other gene delivery strategies. The drug product ... team is also investing in building new platforms to support complex formulations such as lipid nanoparticles, Antibody Drug Conjugates and AAV and other non-viral vector delivery. We are seeking highly motivated professionals with extensive experience in… more
- Lilly (Indianapolis, IN)
- …includes active investments in Oligonucleotide development, nanomedicines for tissue specific targeting and other gene delivery strategies. The drug product ... team is also investing in building new platforms to support complex formulations such as lipid nanoparticles, Antibody Drug Conjugates and AAV and other non-viral vector delivery. We are seeking highly motivated professionals with an experience in developing… more
- Pfizer (Groton, CT)
- …bring innovative approaches to tackle complex protein and RNA biology and diverse targeting modalities. As part of this early discovery group, the individual will ... small molecule mechanism of action. The successful candidate will integrate gene editing methods with high-dimensional functional assays and physiologically relevant… more
- Editas Medicine (Cambridge, MA)
- …allowing us to harness the power and potential of CRISPR/Cas9 and CRISPR/Cpf1 (Cas12a) gene editing. We believe our people are at the core of everything we do, ... must have a proven track record in the discovery and development of drugs targeting diseases of non-CNS/peripheral tissues at least through IND, with more than one… more
- Rush University Medical Center (Chicago, IL)
- …will lead research efforts on human iPSC-based disease modeling or/and CRISPR gene perturbations. The job will perform experiments, analyze data, compile results, ... brain organoid cultures, high-content imaging, molecular biology, viral packaging, CRISPR gene perturbations and data analysis. Exemplifies the Rush mission, vision… more
- Lilly (Indianapolis, IN)
- …efforts and support pipeline projects. The focus will be on therapeutics targeting obesity, metabolic disease, and dyslipidemia. You should have extensive experience ... on samples from tissues and cells including RNA/gDNA isolation and analysis, gene and protein expression analyses, and other analytical techniques. + Demonstrate the… more
- UCLA Fielding School of Public Health (Los Angeles, CA)
- …analyze data and lead projects in vascular biology, focusing on high-resolution gene expression profiling techniques. Responsibilities: + Collaborate with the PI and ... the lab. + Conduct innovative research in vascular biology, specifically targeting intracranial artery disease. + Utilize techniques like western blotting, qPCR,… more
- Actalent (Brooklyn, NY)
- …Qualifications: * Have a minimum of 3 years of experience directly culturing and targeting human PSC lines * Have 1-3 years of experience differentiating PSCs to ... and/or siRNA, as well as the use of * CRISPR/Cas9 gene editing and homologous recombination to study gene function. * Must be fluent working with MS software,… more
- Lilly (Indianapolis, IN)
- …owned subsidiary of Eli Lilly and Company, we are developing a pipeline of gene therapies to slow or stop the underlying disease process for patients with ... for neurodegenerative diseases. Our programs utilize a precision medicine approach targeting patient populations with urgent unmet needs, where there are currently… more
- University of Washington (Seattle, WA)
- …on the development, characterization, and refinement of vaccines and therapeutics targeting infectious diseases and cancers. This position will support projects ... Mouse handling, injections (IM, SQ, IP, RO), ear punching, vaccinations ( Gene Gun, IM, Intranasal, among other routes), challenge inoculations (influenza,… more
- Regeneron Pharmaceuticals (Cambridge, MA)
- …contract lab testing and supporting safety testing for novel drug products targeting oncological indications and providing oversight for the testing of release, ... years of relevant experience. Biopharmaceutical/industry experience in the cell and gene therapy space is strongly preferred. Must have experience with environmental… more
- University of Rochester (Rochester, NY)
- …coordination and execution of experiments to establish the function and therapeutic targeting of various oncogenes of interest in myeloid leukemia to the principal ... immunohistochemistry. + Animal experiments, breeding and maintenance of wild-type and gene specific knockout mice under development. Xenografting cancer cells in… more
- Emory Healthcare/Emory University (Atlanta, GA)
- …for mRNA and other RNA-based drugs. The drugs may consist of vaccines, gene replacement therapies, mRNA-encoded antibodies, CRISPR gene editing therapies, and ... programs will be on extrahepatic delivery, and will therefore require both de- targeting the liver and increasing delivery to other tissues. Prepares and publishes… more