• Principal Scientist I

    Genentech (Pleasanton, CA)
    …better tomorrow. **The Opportunity** We are seeking a highly motivated and innovative Principal Scientist to join our Molecular Diagnostics R&D team in ... future of molecular diagnostics at Roche. **Your Role and Responsibilities** As a Principal Scientist , you will lead from the bench and be a key technical leader… more
    Genentech (12/11/25)
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  • Principal Scientist , Nasal Sprays

    Kelly Services (South San Francisco, CA)
    Kelly(R) Science & Clinical is seeking a Principal Scientist for a **remote** direct hire opportunity with one of our clients, a neuroscience-focused ... at Hiring Experts. **Workplace: Remote (US)** **Pay:** 160,000-190,000/year **Position title:** Principal Scientist , Nasal Sprays **Position type:** Direct hire… more
    Kelly Services (11/21/25)
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  • Principal Scientist - Clinical…

    Amgen (South San Francisco, CA)
    …Join us and transform the lives of patients while transforming your career. ** Principal Scientist - Clinical Pharmacology, Modeling & Simulation** **What you ... Clinical Pharmacology, Modeling & Simulation Department at Amgen is seeking a Principal Scientist . In this vital role, you will drive innovative modeling and… more
    Amgen (09/22/25)
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  • Senior Principal Scientist

    Merck (South San Francisco, CA)
    **Job Description** **Senior Principal Scientist Translational Medicine, Immunology** Translational Medicine in our Research & Development Division is ... Therapeutic Area Lead in Translational Medicine. **Primary responsibilities for the Senior Principal Scientist include the following:** + Key member of an… more
    Merck (12/03/25)
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  • Associate Principal Scientist

    Merck (South San Francisco, CA)
    …seeking an exceptional and experienced scientist in the role of Associate Principal Scientist in the South San Francisco Discovery Biologics group. The ... qualified candidate will be a scientist with a breadth and depth of expertise in immunization-based antibody discovery, including but not limited to expertise in… more
    Merck (12/12/25)
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  • Associate Principal Scientist

    Merck (South San Francisco, CA)
    …Pharmacokinetics, Dynamics, Metabolism and Bioanalytics (PDMB) group is seeking an Associate Principal Scientist to contribute to our Company's biologics, drug ... conjugates, and novel modality discovery and development pipeline. The Associate Principal Scientist will be primarily discovery team-facing and is expected to… more
    Merck (12/04/25)
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  • Principal Scientist , Group Leader,…

    Genentech (South San Francisco, CA)
    **The Position** **The Opportunity** We are seeking an exceptional Principal Scientist (Group Leader) to join our world-class Antibody Engineering Department, ... areas + Drive innovation to solve them through antibody engineering Our new Scientist /Group Lead will help shape the future of our antibody drug capabilities and… more
    Genentech (12/06/25)
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  • Principal Scientist , Oncology…

    Gilead Sciences, Inc. (Foster City, CA)
    …together. **Position Overview:** We are seeking a highly motivated and creative Principal Scientist to support Gilead's growing Oncology targeted large molecule ... portfolio. The successful candidate will be an integral senior member of a high performing research team dedicated to (i) identifying and validating novel targets for T cell Engagers, (ii) developing next-generation approaches to make T cell engagers safer and… more
    Gilead Sciences, Inc. (12/11/25)
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  • Principal Scientist , Biologics…

    Gilead Sciences, Inc. (Foster City, CA)
    …Join Gilead and help create possible, together. **Job Description** The Principal Scientist , Biologics Pivotal Formulation and Process Development role ... is part of the collaborative and interdisciplinary CMC development team aiming to use state-of-the art technologies and innovative methodologies to advance medicines into the clinic. The success candidate is expected to bring relevant technical expertise,… more
    Gilead Sciences, Inc. (11/19/25)
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  • Principal Scientist , Quality…

    Gilead Sciences, Inc. (Foster City, CA)
    …their aspirations. Join Gilead and help create possible, together. **Job Description** The Principal Scientist , Quality Control (QC) Lead will be responsible for ... the strategic oversight and operational execution of cGMP analytical testing in support of small molecule clinical development programs. The role provides leadership for assigned programs across a range of QC activities, ensuring that testing, documentation,… more
    Gilead Sciences, Inc. (11/05/25)
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  • Principal Scientist , Preclinical…

    Merck (South San Francisco, CA)
    …Pharmaceutical Sciences (DPS) group based in South San Francisco, CA is seeking an Principal Scientist with small molecule and peptide experience. DPS is a ... multi-disciplinary research group that provides drug delivery, solid state crystal form characterization, pre-formulation and formulation support and small molecule and biologics developability assessments at the development and drug discovery interface. Our… more
    Merck (12/03/25)
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  • Associate Principal Scientist

    Merck (South San Francisco, CA)
    …Enabling Capabilities (Analytical R&D) is seeking applicants for an Associate Principal Scientist position available at our research laboratories located ... in South San Francisco, California. The successful candidate must be able to collaborate in a dynamic, integrated, and multidisciplinary team environment. A broad range of tools (eg high-resolution mass spectrometry, chromatography, spectroscopy) are… more
    Merck (12/02/25)
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  • Senior Principal Scientist

    Merck (South San Francisco, CA)
    **Job Description** The Senior Director (Sr. Principal Scientist ) has primary responsibility for the strategic planning and directing clinical research ... activities involving investigational compounds in Immunology. With a focus on late-stage development, the Senior Clinical Director will manage the entire cycle of clinical development, including determination of appropriate disease indications to pursue and… more
    Merck (12/02/25)
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  • Senior Principal Scientist , Peptide…

    Genentech (South San Francisco, CA)
    …We are seeking a highly motivated and experienced Medicinal Chemist (Senior Principal Scientist ) to join our innovative research and development team. ... This is a technical leadership position within our Peptide Therapeutics department, focused on advancing Peptide Therapeutics. The ideal candidate will be a significant contributor and a proven leader, responsible for optimizing and advancing novel peptide… more
    Genentech (11/06/25)
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  • Principal Scientist , Computational…

    Frontier Medicines (South San Francisco, CA)
    …Medicines is seeking a highly motivated individual to fill the position of Principal Scientist , Computational Chemistry. The successful candidate will play a ... leading role in developing medicinal chemistry optimization strategies for key drug discovery programs. This individual will review experimental results, develop SAR hypotheses for activity, selectivity, and properties, and make design suggestions to improve… more
    Frontier Medicines (11/04/25)
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  • Lab Head, Principal Scientist

    Genentech (South San Francisco, CA)
    …is thrilled to announce a unique opportunity for a highly skilled, highly motivated Principal Scientist to lead a lab-based research group. We seek an ... exceptional candidate with expertise in the biology of hormone-dependent cancers, specifically of the breast and prostate, who will be dedicated to discovering and developing new therapies. The successful candidate will work closely with our Drug Development,… more
    Genentech (10/29/25)
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  • Principal Applied Scientist

    Amazon (Sunnyvale, CA)
    …the development of industry-leading technology with multimodal systems. As a Principal Scientist within the Artificial General Intelligence (AGI) organization, ... General Intelligence (AGI) team is looking for a passionate, talented, and inventive Principal Applied Scientist with a strong deep learning background, to lead… more
    Amazon (11/19/25)
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  • Principal Applied Scientist

    Amazon (Palo Alto, CA)
    …responsibilities include but are not limited to: Improving Auction Mechanism: The Principal Scientist will reimagine auction mechanisms to holistically optimize ... Advancing Scientific and Technical Capabilities: As a senior leader, the Principal Scientist will play a critical role in elevating the team's scientific… more
    Amazon (10/25/25)
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  • Principal Applied Scientist , AGI…

    Amazon (Sunnyvale, CA)
    Description As a Principal Scientist within the Artificial General Intelligence (AGI) organization, you are a trusted part of the technical leadership. You bring ... that affect the way we build and integrate algorithms. A Principal Applied Scientist will solicit differing views across the organization and are willing… more
    Amazon (11/19/25)
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  • Principal Applied Scientist

    Amazon (Palo Alto, CA)
    …products that directly help them create, optimize, and grow their campaigns. As a Principal Scientist , you will play a critical role in elevating the team's ... AI, join us in shaping the future of advertising. Key job responsibilities The Principal Applied Scientist in Advertiser Guidance team will lead 50+ builders in… more
    Amazon (10/25/25)
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